PEG Modified Upconverting Nanoparticles

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Product Details:

Ph Level Neutral (when dispersed in water)
Molecular Formula NaYF4:Yb,Er/Tm/Ho@PEG (representative)
Form Powder or aqueous suspension
Shape Spherical, uniform morphology
Storage Store at 28C, protect from light and moisture
Other Names UCNPs, PEGylated UCNPs
Smell Odorless
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PEG Modified Upconverting Nanoparticles Product Specifications

Melting Point Not applicable / nan
Solubility Water soluble (due to PEG modification)
Purity >99%
Application Bioimaging, biosensing, drug delivery, photodynamic therapy, in-vivo imaging
Chemical Name PEG-Modified Upconverting Nanoparticles
Classification Inorganic nanoparticle
Other Names UCNPs, PEGylated UCNPs
Standard Laboratory reagent specification
Boiling point Not applicable / nan
Usage Biomedical research, imaging, diagnostics, therapeutic delivery
Form Powder or aqueous suspension
Poisonous Yes
Smell Odorless
Ph Level Neutral (when dispersed in water)
Main Material Lanthanide-doped upconverting nanoparticles (typically NaYF4:Yb,Er/Tm/Ho) with PEG (Polyethylene glycol) surface modification
Grade Research grade
Shape Spherical, uniform morphology
Storage Store at 28C, protect from light and moisture
Molecular Formula NaYF4:Yb,Er/Tm/Ho@PEG (representative)
Type PEG-Modified Upconverting Nanoparticles

Particle Size 2050 nm (customizable on request)
Cytotoxicity Low, compatible with mammalian cells
Surface Coating PEG (Polyethylene Glycol), hydrophilic and biocompatible
Surface Charge (zeta potential) Typically neutral or slightly negative due to PEGylation
Shelf Life 12 months (if properly stored)
Customization Available Surface functionalization, emission color, particle size, ligand exchange
Emission Wavelength Varies (commonly green/red emission, e.g., 540 nm, 650 nm)
Dispersibility Excellent in water and biological media
Excitation Wavelength Typically 980 nm (near-infrared)
Stability Stable in physiological buffers and aqueous solution

PEG Modified Upconverting Nanoparticles Trade Information

Payment Terms Cash Advance (CA), Paypal, Telegraphic Transfer (T/T), Cash in Advance (CID), Cheque
Main Domestic Market All India

Product Description

PEG Modified Upconverting Nanoparticles

Chemical Name	PEG-Modified Upconverting Nanoparticles
Catalog code	NCZ-UCNP-103
Appearance	white solution
Solvent	Water
Excitation wavelength	975 nm
MF	NaYREF4(RE: Yb, Er, Tm, Gd, Mn, Lu) @PEG
CAS Number	7681-49-4(Sodium fluoride)
Sensitizer	Ytterbium (Yb3+)
Concentration	5 mg/mL, Concentration Customization: Possible
Particle Size and Morphology	35 nm, nanosized spheres
Surface Modified	PEG
Form	Dispersion/Powder

Superior Biocompatibility and Hydrophilicity

The PEGylated surface ensures these nanoparticles are both highly hydrophilic and biocompatible. This modification supports their dispersibility in biological media and minimizes cytotoxicity, which makes them suitable for in vivo experiments involving mammalian cells.

Tunable Optical Properties for Versatile Applications

With customizable emission wavelengths and particle sizes, these upconverting nanoparticles can be tailored for specific bioimaging, biosensing, and therapeutic needs. Near-infrared excitation allows deeper tissue penetration and reduced background autofluorescence, enhancing imaging precision.

Stable and Reliable Performance

Designed for robust performance, PEG Modified Upconverting Nanoparticles exhibit superior stability in aqueous solutions and physiological buffers. When stored properly at 28C, shielded from light and moisture, they retain functionality for up to 12 months, ensuring reproducible results in research and clinical studies.

FAQs of PEG Modified Upconverting Nanoparticles:

Q: How do PEG Modified Upconverting Nanoparticles enhance biomedical imaging applications?

A: These nanoparticles efficiently convert near-infrared excitation into visible light, enabling high-contrast bioimaging with minimized autofluorescence and deeper tissue penetration due to their unique emission wavelengths and the biocompatible PEG coating.

Q: What is the recommended storage condition to maintain nanoparticle stability?

A: PEG Modified Upconverting Nanoparticles should be stored between 28C and protected from light and moisture to preserve their stability and function throughout the 12-month shelf life.

Q: When should I consider customizing the particle size or surface functionality of these nanoparticles?

A: Customization is recommended when specific research protocols require particular emission colors, targeting ligands, or tailored sizes for optimized delivery, imaging resolution, or therapeutic efficacy.

Q: Where can these upconverting nanoparticles be utilized besides bioimaging?

A: Apart from bioimaging, these nanoparticles can be employed in drug delivery, biosensing, photodynamic therapy, and diagnostic research due to their versatile opto-physical properties and biocompatibility.

Q: What process is used to achieve hydrophilicity and low cytotoxicity in these nanoparticles?

A: The nanoparticles are modified with a polyethylene glycol (PEG) surface coating, which imparts hydrophilicity, reduces cytotoxicity, and improves dispersibility in aqueous and biological media.

Q: How is cytotoxicity addressed for these nanoparticles in cellular applications?

A: Their PEGylated surfaces ensure low cytotoxicity, making them compatible with mammalian cells and suitable for long-term bioimaging or therapeutic experiments.

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